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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
38.79
Human Site:
Y309
Identified Species:
53.33
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
Y309
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
Y309
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
Y309
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
Dog
Lupus familis
XP_547091
832
93293
Y537
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
Y309
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
Rat
Rattus norvegicus
Q62673
603
68295
Y309
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
A206
I
A
P
R
F
S
I
A
P
N
S
L
D
H
G
Chicken
Gallus gallus
NP_001025810
595
66904
Y299
D
E
F
F
T
S
G
Y
I
P
S
R
L
P
T
Frog
Xenopus laevis
P70032
598
68193
Y300
D
E
F
F
T
S
G
Y
I
P
S
R
L
P
T
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
Y295
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
K281
F
E
F
L
K
G
S
K
V
P
M
F
L
P
S
Honey Bee
Apis mellifera
XP_396707
575
66141
F279
D
P
F
F
T
C
G
F
M
P
L
S
L
P
L
Nematode Worm
Caenorhab. elegans
P34331
649
73615
F294
D
G
F
F
K
S
G
F
M
P
T
R
L
P
V
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
Y283
D
E
F
F
T
T
G
Y
L
P
P
Q
L
P
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
K292
I
L
Q
H
P
F
L
K
N
A
N
N
I
P
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
G169
T
I
L
K
T
T
C
G
T
P
N
Y
V
A
P
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
F337
E
I
M
D
Y
V
W
F
R
G
T
F
P
P
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
86.6
86.6
80
N.A.
33.3
53.3
60
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
93.3
93.3
80
N.A.
40
73.3
80
86.6
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
6.6
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
0
0
0
0
0
6
6
6
36
0
0
6
0
% A
% Cys:
0
0
0
0
0
6
6
0
0
0
0
0
0
0
0
% C
% Asp:
71
0
0
6
0
0
0
0
0
0
0
0
6
0
0
% D
% Glu:
6
65
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
6
0
77
71
6
6
0
18
0
0
0
12
0
0
0
% F
% Gly:
0
6
0
0
0
6
71
6
0
6
0
0
0
0
6
% G
% His:
0
0
0
6
0
0
0
0
0
0
0
0
0
6
0
% H
% Ile:
12
12
0
0
0
0
6
0
48
0
0
0
6
0
36
% I
% Lys:
0
0
0
6
12
0
0
12
0
0
0
0
0
0
6
% K
% Leu:
0
6
6
6
0
0
6
0
6
0
6
6
77
0
6
% L
% Met:
0
0
6
0
0
0
0
0
12
0
12
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
6
6
12
6
0
0
0
% N
% Pro:
0
6
6
0
6
0
0
0
6
83
6
0
6
89
6
% P
% Gln:
0
0
6
0
0
0
0
0
0
0
0
6
0
0
0
% Q
% Arg:
0
0
0
6
0
0
0
0
6
0
0
59
0
0
0
% R
% Ser:
0
0
0
0
0
65
6
0
0
0
18
6
0
0
12
% S
% Thr:
6
0
0
0
71
12
0
0
6
0
12
0
0
0
24
% T
% Val:
0
0
0
0
0
6
0
0
6
0
0
0
6
0
6
% V
% Trp:
0
0
0
0
0
0
6
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
6
0
0
59
0
0
0
6
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _